Scientist, In Vivo Pharmacology
Core
Design, execute, and interpret preclinical in vivo studies in murine models of cancer and immune-mediated diseases to evaluate novel therapeutic candidates.
Role type
Senior IC in vivo pharmacology scientist
Builds
Preclinical efficacy and mechanistic data for oncology and immunology cell therapy programs
Domain
Biopharma / Oncology / Immunology / Cell Therapy
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
in vivo study design and execution, murine model handling, compound administration, tumor implantation, immune cell transfers, longitudinal sampling, IVIS imaging operation and analysis, pharmacodynamic evaluation, mechanism-of-action assessment, combination therapy hypothesis testing, ELN documentation, statistical data interpretation
Preferred skills
PhD in Pharmacology/Immunology/Oncology/Cell Biology, industry R&D experience, tumor model expertise, immune-mediated disease model expertise, biomarker familiarity, molecular assay familiarity
Technologies
IVIS imaging systems, GraphPad Prism, Excel
Responsibilities
Design and interpret in vivo studies in murine models of cancer and immune-mediated diseases; Perform and oversee in vivo studies including compound administration, disease induction, tumor implantation, immune cell transfers, longitudinal sampling, and animal monitoring; Develop experimental strategies to evaluate pharmacodynamic, efficacy, mechanism-of-action, and combination therapy hypotheses; Independently operate and apply imaging technologies, including IVIS, to support efficacy and mechanistic studies; Troubleshoot technical and scientific challenges and develop solutions to improve study outcomes; Analyze and interpret complex datasets using GraphPad Prism, Excel, and other data analysis tools; Integrate in vivo, pharmacodynamic, biomarker, and mechanistic data to generate actionable scientific insights; Prepare and present study results, scientific reports, and project updates to cross-functional teams and leadership; Ensure compliance with BMS policies, IACUC regulations, and animal welfare standards
Seniority
Senior, hands-on IC