Senior Manager, PharmSci Clinical Manufacturing Planning

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Job Description

Objective / Purpose:

This role is part of the Strategic Planning Group within PharmSci Clinical Manufacturing Planning, which is responsible for delivering robust, risk‑appropriate Drug Substance (DS) and Drug Product (DP) production plans across Takeda’s clinical portfolio.

The Senior Manager contributes to the team’s delivery of critical planning capabilities by owning the development and execution of program-level production plans, ensuring alignment to demand, manufacturing constraints, and supply continuity objectives.

This role translates cross-functional inputs into feasible, risk-managed, and decision-ready plans, enabling governance forums to proactively assess tradeoffs and respond to changes in demand, timelines, or supply conditions.

Through application of standardized planning rules and continuous improvement of planning practices, the Senior Manager strengthens the operational effectiveness and reliability of the planning function.

Accountabilities:

KEY INTERFACES:

• Internal: CMC / PharmSci, GCSC, Quality, Finance, Program Teams
• External: CDMOs, vendors

DECISION-MAKING AUTHORITY:

• Owns program-level planning outputs and risk responses
• Recommends tradeoff decisions to Associate Director / Director

CORE COMPETENCIES:

• Strong analytical and problem-solving capability
• Effective stakeholder engagement across functions
• Ability to translate strategy into execution
• Strong communication and presentation skills
• Anticipation and mitigation of supply risks

KPIs / SUCCESS MEASURES:

• Robust, risk-adjusted plans
• Reduction in supply disruptions
• Inventory balance
• Timeliness of outputs
• Contribution to cost efficiency

ACCOUNTABILITIES:

• Develop and maintain integrated DS/DP production plans for assigned programs or assets, ensuring plans are feasible, risk-managed, and aligned with program requirements and manufacturing constraints.
• Translate demand signals, technical inputs, and network constraints into decision-ready production plans, scenarios, and inventory strategies.
• Lead development of alternative planning scenarios to evaluate timing, capacity, inventory, and cost tradeoffs under changing conditions.
• Identify, quantify, and communicate supply risks and mitigation strategies, and incorporate agreed actions into planning outputs.
• Align cross-functional stakeholders, including CMC, CDMO managers, and GCSC planners, on planning assumptions, recommended actions, and execution priorities.
• Prepare governance, escalation, and decision-support materials for planning reviews and portfolio discussions.
• Monitor execution against plan, assess changes in program or manufacturing conditions, and adjust plans proactively to maintain supply continuity.
• Drive adoption of standardized planning practices and contribute to continuous improvement of planning processes, tools, and governance frameworks.

Education & Competencies (Technical and Behavioral):

• Bachelor’s degree in Life Sciences, Engineering, Supply Chain, Operations, Pharmacy, Business, or other scientific/technical discipline required; advanced degree preferred.
• 6+ years of relevant experience in pharmaceutical, biotech, clinical manufacturing, supply chain planning, CMC, or contract manufacturing environments preferred.
• Demonstrated experience developing and managing production plans, supply scenarios, inventory strategies, or demand/supply balancing processes in a regulated environment.
• Strong working knowledge of DS/DP planning principles, including how manufacturing constraints, demand changes, inventory posture, and lead times affect supply continuity.
• Experience applying scenario modeling and risk-based planning approaches to evaluate alternatives, identify constraints, and support cross-functional decision-making.
• Sound knowledge of GxP requirements and ability to incorporate GMP/GDP/GCP considerations into planning outputs, communications, and escalation decisions.
• Strong analytical and quantitative skills, including ability to synthesize data, identify trends, and generate actionable planning recommendations.
• Demonstrated ability to influence cross-functional stakeholders and align teams around assumptions, recommendations, and execution priorities.
• Strong communication and presentation skills, with the ability to prepare clear, concise, and decision-ready planning materials for governance and leadership review.
• Proven ability to manage multiple projects of moderate complexity simultaneously while maintaining high-quality outputs and meeting timelines.
• Certifications such as APICS/CPIM/CSCP, PMP, Lean, or Six Sigma are preferred but not required.
• Demonstrated track record of improving planning processes, tools, templates, or ways of working within a function or team setting.

Additional Information

• Location: Lexington, MA

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Lexington, MA

U.S. Base Salary Range:

$137,000.00 - $215,270.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Lexington, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.