Senior Director, AIRx Medicinal Chemistry
Core
Design and optimize drug candidates using deep SAR intuition, multi-parameter optimization, and ADME-embedded design principles while critically evaluating AI/ML-generated proposals.
Role type
Senior Director, medicinal chemistry (AI-enabled drug design)
Builds
Differentiated medicine candidates delivered to the clinic at speed
Domain
Pharmaceutical drug discovery, AI-enabled molecular design
Deliverable
production ML models
Required skills
SAR-driven design, ADME optimization, multi-parameter optimization, CRO program direction, AI/ML design tool interpretation, structure-based drug design, strategic oversight of synthesis programs
Preferred skills
Experience in Takeda Research portfolio therapeutic areas, SWAT team or rapid-response team environment experience
Technologies
Generative AI tools, X-ray crystallography, cryo-EM
Responsibilities
Design and optimize drug candidates using deep SAR intuition and ADME principles; Integrate and critically evaluate AI/ML-generated design proposals; Partner with Computational Chemistry to close DMTA cycles rapidly; Provide strategic oversight of CRO synthesis programs; Embed selectivity, developability, and IP considerations into design decisions; Interpret structural biology data to guide optimization
Seniority
Senior Director, hands-on IC with strategic oversight
