Scientist, RNA Biology
Core
Establish and advance robust capabilities for the design, production, purification, and quality control of research-grade RNA payloads used in lipid nanoparticle (LNP) discovery and development for cancer therapies.
Role type
Senior IC RNA Biology Scientist (LNP payload manufacturing)
Builds
Research-grade RNA payloads for LNP discovery and development
Domain
Biopharmaceuticals / Oncology / RNA therapeutics
Required skills
mRNA production and characterization, RNA sequence design, nucleotide chemistry, purification, analytical methods, fit-for-purpose release criteria, LNP formulation compatibility, process development, data analysis, troubleshooting, mentorship
Preferred skills
Circular RNA, self-amplifying RNA, modified nucleotides, cap chemistry, untranslated-region engineering, RNA structure, innate immune sensing, scaling/automating RNA workflows, method-transfer packages, cell therapy/oncology program support
Technologies
Liquid-handling systems, chromatography, tangential-flow filtration, capillary electrophoresis, HPLC, spectrophotometry, fluorometric assays, qPCR, dPCR
Responsibilities
Own end-to-end research-scale RNA production (template prep, IVT, capping, purification, storage); Develop and optimize workflows for linear, circular, and self-amplifying RNA; Design and evaluate RNA sequence/chemistry variables; Establish RNA quality-control methods and acceptance criteria; Operate and troubleshoot research instruments; Partner with LNP formulation scientists; Develop data packages for comparability; Lead investigations of failed experiments; Generate hypotheses and design experiments; Mentor junior scientists
Seniority
Senior, hands-on IC