Associate Principal Scientist, TCE Discovery & Biology
Core
Lead defined biology workstreams for next-generation T-cell engager (TCE) therapeutics, bridging laboratory execution and project-level scientific leadership to drive molecule optimization and progression decisions.
Role type
Associate Principal Scientist (TCE Discovery & Biology)
Builds
T-cell engager (TCE) therapeutics for immuno-oncology
Domain
Immuno-oncology / T-cell biology / Therapeutic discovery
Required skills
T-cell biology, tumor immunology, mammalian cell-based functional assays, TCE/bispecific antibody expertise, primary human immune-cell culture, multiparameter flow cytometry, experimental design and troubleshooting, assay cascade development, matrix leadership
Preferred skills
Lead optimization experience, antigen-density biology, serial-killing assays, patient-derived sample handling, CRO study oversight, in vivo pharmacology integration
Technologies
Flow cytometry, co-culture systems, organoids, ex vivo models
Responsibilities
Design and execute critical in vitro TCE experiments; establish and optimize T-cell and tumor-cell co-culture systems; own development of quantitative assay cascades; lead defined biology workstreams within TCE discovery programs; design and execute mechanistic studies addressing target abundance and resistance; mentor junior scientists and oversee external partner studies
Seniority
Senior, hands-on IC with matrix leadership