Principal Engineer – HVAC, Clean Utilities & Process
Core
Site-wide technical expert and subject-matter expert for GMP HVAC systems, clean utilities, manufacturing systems, and process engineering, ensuring safe, compliant, and efficient biologics manufacturing operations.
Role type
Principal Engineer (HVAC, Clean Utilities & Process)
Builds
Biologics manufacturing operations, clean utility systems, and GMP-compliant manufacturing environments
Domain
Biopharmaceutical manufacturing / HVAC & Process Engineering
Required skills
GMP compliance, HVAC system design, clean utility management, risk management, capital project leadership, root-cause analysis, asset life-cycle management, Lean principles, cross-functional collaboration, technical mentoring
Preferred skills
Advanced knowledge of commercial biologics manufacturing, industry networking, strategic planning, zero-based budgeting
Technologies
WFI systems, pure steam, OFCA, specialty gases, bioreactors, centrifuges, automated systems, environmental control systems (via careerplan.io/jobs/R-261281-principal-engineer-hvac-clean-utilities-process-at-astrazeneca)
Responsibilities
Lead investigations into major deviations and complex technical issues; Serve as technical expert on large capital projects from concept to operational readiness; Develop departmental engineering tools, standards, and training materials; Coach and mentor engineers, technicians, and interns; Ensure engineering solutions comply with GMP, safety, and regulatory requirements; Champion continuous improvement and Lean principles across the site
Seniority
Principal, strategic leadership & hands-on technical expertise