Principal Scientist - Induced Proximity Medicinal Chemistry
Core
Design and advance small-molecule induced-proximity medicines (PROTACs, molecular glues) for clinical development, integrating molecular design with ternary-complex biology and drug-like properties.
Role type
Principal Scientist, hands-on IC medicinal chemist
Builds
Small-molecule degraders and functional modulators for oncology, inflammation, general medicine, and rare disease
Domain
Biotech / Medicinal Chemistry / Protein Degradation
Required skills
Synthetic organic chemistry, medicinal chemistry, PROTAC design, molecular glue design, SAR development, structure-property-activity relationships, ternary-complex analysis, DMPK interpretation, patent inventorship, peer-reviewed publications
Preferred skills
Experience with targeted-chimera modalities, parallel synthesis, route design, biophysical/biochemical data translation, cross-functional collaboration, mentorship
Technologies
PROTACs, molecular glues, heterobifunctional degraders, E3 ligases, chemical biology tools
Responsibilities
Design, synthesize, purify, and characterize small molecules for induced-proximity programs; lead hypothesis-driven SAR and structure-property-activity relationships; collaborate with chemical biology, structural biology, DMPK, and computational teams; develop strategies for modality-specific challenges; mentor scientists and research associates; generate results for publications and patents
Seniority
Principal, hands-on IC with mentorship responsibilities
