Principal Scientist - Cardiometabolic Disorders
Core
Provide scientific leadership for the discovery and preclinical development of next-generation therapeutics for obesity and related cardiometabolic diseases.
Role type
Principal Scientist (Drug Discovery, Preclinical)
Builds
Innovative therapeutic candidates for obesity and cardiometabolic diseases
Domain
Biotechnology / Pharmacology / Cardiometabolic Disorders
Required skills
Translational pharmacology strategy, in vitro and in vivo study design, GPCR biology, pharmacological characterization of biologics, data integration for decision making, scientific leadership, mentoring
Preferred skills
GPCR-based assay development, peptide/antibody therapeutic expertise, mechanism-of-action studies, cross-functional collaboration, scientific publication
Technologies
GPCR-targeted drug discovery platforms, functional signaling assays, ligand-binding assays, PK/PD analysis tools
Responsibilities
Lead target identification and validation through candidate selection; Design and interpret pharmacology studies (efficacy, MoA, PK/PD); Mentor scientists and lead cross-functional teams; Present findings to senior leadership and external audiences; Contribute to scientific strategy and publications
Seniority
Principal, hands-on IC with leadership