Postdoctoral Research Fellow — Clonal Evolution and Genome Engineering in Inherited Bone Marrow Failure Disorders
Core
Study clonal evolution and leukemic transformation in inherited bone marrow failure syndromes, specifically Shwachman-Diamond syndrome, using patient samples and iPSC models.
Role type
Postdoctoral Research Fellow (IC)
Builds
Research findings on disease trajectory and therapeutic genome editing strategies
Domain
Biomedical research, Hematology, Cancer Biology, Genome Engineering
Deliverable
research
Required skills
Molecular and cell biology methods, Single-cell RNA sequencing, Quantitative data analysis, Scientific writing
Preferred skills
CRISPR/Cas9 or base/prime editing, Primary hematopoietic stem cell culture, NGS analysis, R or Python
Technologies
CRISPR, iPSC, scRNA-seq, qPCR, Flow cytometry, Western blot
Responsibilities
Conduct CRISPR/base-editing screens, Analyze single-cell genomics data, Culture primary patient samples and iPSC lines
Seniority
Postdoctoral Fellow