Scientist / Sr. Scientist —Cell, Molecular & Chemical Biology (Taosheng Chen Lab)
Core
Develop and characterize mechanisms of action for novel chemical probes (agonists, antagonists, degraders) targeting nuclear receptors PXR and CAR to combat drug resistance and tumorigenesis.
Role type
Senior IC cell/molecular/chemical biologist (nuclear receptor signaling)
Builds
Novel chemical probes and therapeutic strategies for nuclear receptor-driven transcriptional networks
Domain
Oncology / Chemical Biology / Nuclear Receptor Signaling
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Cell biology, Molecular biology, Chemical biology, Small-molecule mechanism of action evaluation, Protein-protein interactions, Transcriptional profiling, Data analysis and interpretation, Laboratory protocol development, Multidisciplinary collaboration
Preferred skills
Structural biology basics, Medicinal chemistry basics, Murine studies, PROTAC-based approaches
Technologies
Western blotting, Plasmid construction, RNA isolation, Proteomic profiling, Crystal structure analysis
Responsibilities
Design and execute independent studies to test scientific hypotheses, Develop new research protocols and techniques, Process and interpret experimental data to define transcriptional networks, Collaborate with structural biologists and medicinal chemists, Lead integration of findings into manuscripts and publications, Train and oversee laboratory personnel
Seniority
Senior, hands-on IC with leadership responsibilities