Scientist / Sr. Scientist —Cell, Molecular & Chemical Biology (Taosheng Chen Lab)
Core
Develop and characterize mechanisms of action for novel chemical probes (agonists, antagonists, degraders) targeting nuclear receptors PXR and CAR to combat drug resistance and tumorigenesis.
Role type
Senior IC cell and molecular biologist (chemical biology)
Builds
Novel chemical probes and therapeutic strategies for nuclear receptor signaling
Domain
Biomedical research / Chemical biology / Oncology
Required skills
Cell biology, Molecular biology, Chemical biology, Small-molecule mechanism of action evaluation, Protein-protein interactions, Transcriptional profiling, Data analysis and interpretation, Laboratory protocol development
Preferred skills
Structural biology, Medicinal chemistry, Murine studies, PROTAC-based approaches
Technologies
Western blotting, Plasmid construction, RNA isolation, Proteomic profiling, Crystal structures
Responsibilities
Design and execute independent studies to test scientific hypotheses, Develop new research protocols and techniques, Integrate multidisciplinary findings into manuscripts and publications, Train and oversee laboratory personnel, Troubleshoot instrument and equipment issues
Seniority
Senior, hands-on IC