Lead In Vivo Researcher – Yen - Lab - Therapeutic Genome Engineering
Core
Lead in vivo research and therapeutic delivery for genome editing treatments targeting hemoglobinopathies and pediatric catastrophic diseases using humanized models.
Role type
Senior In Vivo Researcher (Therapeutic Genome Engineering)
Builds
Translational pipeline for genome editing therapeutics
Domain
Biotechnology / Gene Therapy / Hematology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
In vivo research with humanized models, immunocompromised strain handling, disease model management, HSC isolation and characterization, MACS, multi-color flow cytometry, aseptic sample collection, in vivo delivery/transplantation, regulatory compliance (ILAR/USDA), protocol refinement, team mentorship, data documentation
Preferred skills
Master's degree or higher, R&D method execution, specialized software/database management, welfare-focused research practices
Technologies
MACS, multi-color flow cytometry, specialized software systems for data maintenance
Responsibilities
Execute complex in vivo studies with specialized humanized and disease-relevant models; Isolate and characterize human HSCs using MACS and flow cytometry; Prepare and maintain advanced humanized research models; Administer in vivo delivery approaches for experimental therapies; Refine protocols to minimize stress and ensure humane endpoints; Mentor early-career team members on procedures and welfare techniques
Seniority
Senior, hands-on IC with leadership responsibilities