Postdoctoral Research Associate - Chemical Biology & Therapuetics
Core
Lead cell and molecular biology efforts to investigate the molecular regulation of PXR, CAR, and CYP3A enzymes, and characterize novel ligands and protein degraders.
Role type
Postdoctoral Research Associate (Chemical Biology & Therapeutics)
Builds
Chemical tools and therapeutic strategies for understanding drug toxicity and resistance
Domain
Chemical biology, structural biology, drug metabolism, nuclear receptor biology
Required skills
cell and molecular biology, structural biology, medicinal chemistry, chemical biology, hypothesis-driven experimental design, protein characterization, transcriptional network analysis
Preferred skills
nuclear receptor biology, protein degradation, drug metabolism, ligand-binding pocket analysis
Technologies
N/A
Responsibilities
Lead biological characterization of novel ligands, inhibitors, and targeted protein degraders; Develop and implement hypothesis-driven cellular and molecular approaches to investigate PXR and CAR regulation; Collaborate with structural biologists and chemists to connect molecular structure with biological activity; Evaluate chemical probes and therapeutic strategies in cellular and in vivo models; Lead multidisciplinary manuscripts and contribute to new research directions
Seniority
Postdoctoral Fellow, independent research lead