Postdoctoral Research Associate - Chemical Biology & Therapuetics
Core
Lead cell and molecular biology efforts to investigate the molecular regulation of PXR, CAR, and CYP3A enzymes, developing chemical tools and therapeutic strategies for drug toxicity and resistance.
Role type
Postdoctoral Research Associate (Chemical Biology & Therapeutics)
Builds
Chemical tools, targeted protein degraders, and therapeutic strategies for drug metabolism and toxicity.
Domain
Chemical biology, structural biology, drug metabolism, nuclear receptor biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
cell and molecular biology, structural biology, medicinal chemistry, chemical biology, hypothesis-driven experimental design, protein characterization, ligand-binding analysis, in vivo model evaluation
Preferred skills
nuclear receptor biology, protein degradation, drug metabolism, chemical biology, structural biology
Technologies
N/A
Responsibilities
Lead biological characterization of novel ligands, inhibitors, and targeted protein degraders; Develop and implement cellular and molecular approaches to investigate PXR and CAR regulation; Collaborate with structural biologists and chemists to connect structure with biological activity; Evaluate chemical probes and therapeutic strategies in cellular and in vivo models; Lead multidisciplinary manuscripts and contribute to new research directions
Seniority
Postdoctoral, independent research lead