Senior PK/PD Expert- Oncology & Dermatology Drug Discovery -CDI
Core
Senior PK/PD Scientist guiding decision-making from early discovery through candidate selection for oncology and dermatology drug discovery programs.
Role type
Senior IC pharmacokinetics/pharmacodynamics scientist
Builds
Innovative therapies for oncology and dermatology
Domain
Pharmaceutical R&D, Oncology, Dermatology
Deliverable
production ML models | product features
Required skills
PK/PD modeling, PBPK modeling, exposure-response characterization, dose and schedule optimization, tumor growth inhibition modeling, skin barrier penetration modeling, biomarker strategy integration, AI/in silico ADMET interpretation, Phoenix NLME proficiency
Preferred skills
Experience with small molecules, biologics, and ADCs, knowledge of immune-oncology mechanisms, experience with human skin explants and iPSC-derived keratinocytes
Technologies
Phoenix NLME
Responsibilities
Serve as PK/PD representative on multidisciplinary project teams; characterize exposure–response relationships for efficacy and safety; support dose and schedule optimization across modalities; integrate PK, PD, and biomarker data for translational predictions; use PBPK models to project tissue distribution including tumor and skin penetration; implement quantitative frameworks for TGI models; translate preclinical findings into first-in-human guidance.
Seniority
Senior, hands-on IC
