Principal Scientist, Epilepsy Research
Core
Lead preclinical epilepsy research using in vivo mouse models and ex vivo electrophysiology to evaluate candidate therapeutics for drug-resistant and pediatric epilepsies.
Role type
Principal Scientist, Epilepsy Research (Preclinical)
Builds
Preclinical data packages for IND-enabling studies and regulatory submissions.
Domain
Biomedical research / Neurology / Epilepsy
Required skills
in vivo electrophysiology (EEG/LFP), brain slice preparation, patch-clamp, rodent epilepsy models, therapeutic development, scientific leadership, grant writing
Preferred skills
genetic mouse models, advanced imaging (calcium imaging, optogenetics), translational biomarker development, gene therapy, regulatory guidelines (FDA/EMA)
Technologies
Clampfit, Spike2, MATLAB, Python
Responsibilities
Design and execute seizure studies in mouse models; perform chronic in vivo electrophysiological recordings; oversee surgical implantation of recording electrodes; develop new in vivo model systems; execute acute and organotypic brain slice preparations; perform whole-cell patch-clamp and field potential recordings; evaluate candidate therapeutics (small molecules, biologics, gene therapy); lead a small team of research scientists; define research priorities and drive experimental strategy; present findings at conferences and in peer-reviewed publications.
Seniority
Principal, scientific leadership & hands-on research