Principal Scientist, Epilepsy Research
Core
Lead preclinical epilepsy research using in vivo and ex vivo electrophysiology to evaluate therapeutic candidates and develop novel mouse models.
Role type
Principal Scientist, Epilepsy Research
Builds
Preclinical data packages for IND-enabling studies and regulatory submissions for CNS therapeutics
Domain
Biomedical research / Epilepsy / Neuropharmacology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
in vivo electrophysiology (EEG/LFP), brain slice preparation, patch-clamp, rodent epilepsy models, therapeutic development, scientific leadership, experimental design
Preferred skills
genetic mouse models, advanced imaging (calcium/optogenetics), translational biomarkers, regulatory guidelines (FDA/EMA), gene therapy
Technologies
Clampfit, Spike2, MATLAB, Python
Responsibilities
Design and execute seizure studies in mouse models; perform chronic in vivo electrophysiological recordings; oversee surgical implantation of recording electrodes; develop and validate new in vivo model systems; execute acute and organotypic brain slice preparations; perform whole-cell patch-clamp and field potential recordings; analyze pharmacological modulation of ion channels; lead a small team of research scientists; define research priorities and drive experimental strategy; present findings at conferences and in publications
Seniority
Principal, hands-on IC with team leadership
