Postdoctoral Researcher - Human Genetics, Proteomics, and Multi-Omics for Drug Target Discovery
Core
Lead independent research projects analyzing biobank-scale human genetics and proteomics data to identify causal proteins and genetic variants for drug target discovery in cardiometabolic diseases.
Role type
Postdoctoral Researcher (Human Genetics & Proteomics)
Builds
Therapeutic targets derived from causal protein and variant identification
Domain
Human genetics, proteomics, multi-omics, biostatistics
Deliverable
production ML models | research
Required skills
Mendelian randomization, GWAS, fine-mapping, colocalization, polygenic scoring, R, Python, Unix/Linux shell, high-performance computing, cloud computing, scientific writing
Preferred skills
biobank-scale data analysis, plasma/tissue proteomics platforms, single-cell or spatial transcriptomics, drug target discovery, international consortia collaboration
Technologies
R, Python, Olink, SomaScan, Slurm, PBS, DNAnexus, Terra, AWS, GCP, Git
Responsibilities
Design and execute independent research projects applying causal inference methods to biobank data; Analyze integrated plasma/tissue proteomics and genotype/phenotype data; Develop and maintain reproducible analysis pipelines on HPC/cloud; Write first-author manuscripts and present at conferences; Prepare grant and fellowship applications; Collaborate with internal team and external consortia; Mentor trainees and support shared infrastructure
Seniority
Postdoctoral Fellow (Independent researcher with mentorship)