Director, Modeling and Simulation
Core
Lead PK/PD and QSP modeling to de-risk drug discovery programs, inform target prioritization, and support regulatory interactions for novel therapies.
Role type
Director, Modeling and Simulation (PK/PD/QSP)
Builds
Mechanistic models for small molecules, antibodies, cell therapies, and LNPs across obesity, oncology, and rare diseases.
Domain
Biotechnology / Pharmacometrics / Drug Discovery
Deliverable
production ML models
Required skills
QSP modeling, PK/PD modeling, mechanistic/physiologically-based modeling, population PK/PD, AI-supported modeling workflows, R, Python, Matlab, Simbiology, NONMEM, Monolix, Pumas
Preferred skills
Agentic modeling workflows, experience with CRO management, external scientific representation
Technologies
R, Python, Matlab, Simbiology, NONMEM, Monolix, Pumas
Responsibilities
Develop QSP and PK/PD models for various modalities and therapeutic areas; Provide guidance to early-stage companies to accelerate timelines from Lead ID to DC; Utilize AI-supported modeling workflows for end-to-end modeling support; Manage a small team of modeling scientists and CROs including scientific oversight and budget accountability; Support regulatory interactions through model-informed drug development (MIDD) approaches.
Seniority
Director, hands-on IC with management responsibilities