Senior Scientist, LNP Formulations
Core
Design and synthesize novel ionizable lipids and optimize lipid nanoparticle (LNP) formulations for nucleic acid delivery.
Role type
Senior Scientist II, Lipid Chemistry & Formulation
Builds
Novel ionizable lipids and optimized LNP molar compositions for gene therapy
Domain
Biotechnology / Gene Therapy / Organic Chemistry
Required skills
multi-step organic synthesis, lipid chemistry, LNP formulation (microfluidic mixing, nanoprecipitation), formulation screening, analytical characterization (NMR, LC-MS, HPLC, DLS), experimental design, data analysis
Preferred skills
nucleic acid delivery (mRNA, DNA, siRNA), computational lipid design, patent/publication record
Technologies
microfluidic mixers, nanoprecipitation equipment, NMR, LC-MS, HPLC-CAD/ELSD, DLS
Responsibilities
Design and synthesize novel ionizable lipids; Lead LNP molar composition design; Prepare LNP formulations for screening; Conduct formulation screening studies; Characterize lipids and LNPs; Collaborate on in vitro/in vivo evaluation; Mentor junior scientists
Seniority
Senior, hands-on IC with mentorship
