Scientist I, Biochemistry & Lead Discovery
Core
Lead biochemical assay development, target engagement studies, and binding characterization for small molecules and heterobifunctionals to support hit-to-lead optimization.
Role type
Senior IC biochemist (lead discovery)
Builds
Biochemical assays and binding data for therapeutic modalities
Domain
Biotechnology / Small molecule drug discovery
Required skills
protein chemistry, biophysics, biochemical assay design, protein purification, high-throughput screening, small-molecule handling, CRO management
Preferred skills
experience with FP, FRET, NanoBRET, or NanoBiT technologies
Technologies
FP, FRET, NanoBRET, NanoBiT
Responsibilities
Lead and execute biochemical assay development to monitor protein/ligand and protein/protein interactions; Apply readout technologies such as FP, FRET, NanoBRET, or NanoBiT across active programs; Drive protein purification and QC processes; Set up and run high-throughput assays; Partner with contract research organizations as needed
Seniority
Senior, hands-on IC