Scientist, In Vivo Pharmacology
Core
Execute preclinical in vivo efficacy, biodistribution, and PK/PD studies in rodent models (including humanized, xenograft, syngeneic, and transgenic mice) to support gene therapy programs.
Role type
Senior In Vivo Pharmacology Scientist
Builds
Preclinical data packages for exploratory and therapeutic gene therapy programs
Domain
Biotechnology / Gene Therapy / Preclinical Pharmacology
Required skills
In vivo rodent study execution, mouse model expertise (immunology/oncology), IACUC protocol writing, animal procedures (blood collection, necropsy, tissue harvest), therapeutic administration, dose calculations, CRO/vivarium management
Preferred skills
NHP protocol familiarity, IVIS acquisition and analysis
Technologies
IVIS, CRO platforms, vivarium systems
Responsibilities
Execute and oversee in vivo efficacy, biodistribution, and PK/PD studies in rodent models; Perform animal procedures including blood collection, necropsy, tissue harvest, and test article administration; Author IACUC protocols and contribute to NHP protocols; Establish relationships with vivariums and CROs; Perform dose calculations and prepare dosing formulations; Ensure study compliance with IACUC protocols and company policies; Analyze tolerability endpoints and communicate results to stakeholders
Seniority
Senior, hands-on IC