Associate Director, LNP Manufacturing
Core
Lead LNP scale-up from R&D to NHP scale, driving upstream/downstream process development and mentoring a team of scientists and engineers.
Role type
Associate Director, LNP Manufacturing
Builds
Programmable medicines (lipid nanoparticle formulations) for in vivo studies
Domain
Biotechnology / Gene Therapy / Lipid Nanoparticle Manufacturing
Required skills
LNP scale-up, upstream/downstream process development, mixing platforms (T-mix, impingement, microfluidics), TFF, LNP analytics (DLS, HPLC, LC-MS), lipid design principles, team leadership
Preferred skills
GMP environment scaling, CDMO management, clinical translation experience, tLNP conjugation at scale, lipid synthesis
Technologies
NanoAssemblr, T-mix, impingement mixers, TFF, DLS, HPLC/CAD, LC-MS
Responsibilities
Lead LNP scale-up from small R&D formulations to NHP scale; Drive upstream and downstream process development; Scale targeted LNPs including conjugation and purification; Run micro- to mid-scale formulation on microfluidics platforms; Integrate QC profiling and method development; Lead and mentor a team of scientists and engineers
Seniority
Senior, hands-on IC with leadership responsibilities