Scientist I, In Vitro Pharmacology
Core
Develop and execute biochemical and cell-based assays to assess Syntein™ activity, target engagement, and mechanism of action to drive discovery programs.
Role type
Scientist I, In Vitro Pharmacology
Builds
Syntein™ therapeutic modality and discovery pipeline
Domain
Biotechnology / Cell Biology / Pharmacology
Required skills
mammalian cell culture, transient and stable transfection, lentiviral transduction, reporter cell lines, TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, reporter gene assays, primary cell culture, tissue dissociation, assay development, intracellular signaling analysis, data records creation
Preferred skills
cellular/high content imaging, image analysis, renal disease biology, preclinical kidney models, in vivo pharmacology, laboratory automation, semi-automated screening workflows
Technologies
Incucyte, Phenix
Responsibilities
Design and execute cell-based and biochemical assays; conceptualize and develop novel assays for diverse target classes; collaborate with Pharmacology team on biochemistry and biophysics projects; contribute to in vivo and ex vivo pharmacology activities; optimize assays for screening funnels; generate and report high-quality data
Seniority
Junior, hands-on IC