Senior Scientist, Protein Engineering
Core
Design, construct, and functionally interrogate large protein variant libraries to link genotype to phenotype at scale for small molecule drug discovery.
Role type
Senior Scientist, Protein Engineering (Hands-on IC)
Builds
Novel platform technology for small molecule drug discovery
Domain
Biotechnology / Protein Engineering / Drug Discovery
Required skills
library-scale molecular cloning, protein display systems, fluorescence-activated cell sorting (FACS), next-generation sequencing analysis, biochemical/biophysical characterization
Preferred skills
protein expression and purification, bioinformatic analysis of variant-level data, machine learning for protein engineering
Technologies
Illumina amplicon sequencing, yeast surface display, mammalian display, phage display, ESM models
Responsibilities
Set technical direction for library design and functional interrogation; Design and test large-scale protein variant libraries; Establish and optimize display, selection, and sorting workflows; Assess library quality and validate outputs via biochemical characterization; Build and evolve the protein-engineering function; Partner with computational colleagues to translate data into platform products.
Seniority
Senior, hands-on IC
