Director, Discovery DMPK
Core
Strategic DMPK leadership for peptide therapeutics, driving ADME strategy, risk mitigation, and progression from discovery to IND-enabling development.
Role type
Director, Discovery DMPK
Builds
AI-enabled DMPK workflows and digital solutions for peptide programs
Domain
Biopharmaceuticals, Peptide therapeutics, Drug Discovery
Deliverable
production ML models
Required skills
Peptide ADME/PK strategy, Human translation (PK/PD, dose projection), Regulatory submission expertise (IND/NDA), CRO management, Bioanalysis, AI tool utilization, Cross-functional leadership
Preferred skills
Biologics experience, Regulated bioanalysis, Advanced AI application in DMPK
Technologies
Phoenix WinNonlin, R
Responsibilities
Establish ADME strategy and align with program milestones; Lead design and interpretation of in vitro/in vivo ADME/PK studies; Integrate DMPK data to influence chemical design; Oversee external CROs and partners; Present DMPK strategies and risk assessments to leadership; Provide regulatory strategy for submissions; Co-lead AI-enabled DMPK workflows; Mentor junior scientists
Seniority
Director, strategic leadership & cross-functional influence