In Vivo Study Specialist
Core
Execute in vivo pharmacology studies in mouse oncology models and prepare high-quality ex vivo assays from tumor and normal tissue for downstream molecular and immune analysis.
Role type
Senior IC in vivo study specialist (oncology)
Builds
Preclinical data for Helicon peptide therapeutics advancing toward clinical development
Domain
Biopharmaceuticals / Oncology drug discovery
Required skills
mouse oncology models (xenograft, syngeneic, PDX, GEMMs), in vivo dosing (IV, IP, SC, PO), tumor measurement and monitoring, serial blood collection and PK sampling, terminal necropsy, ex vivo tissue processing, histology sample prep, molecular sample extraction (RNA/DNA/protein), pharmacology and PK/PD study execution
Preferred skills
minor and major rodent surgical procedures, histology/IHC, qPCR, Western Blot, ELISA, multiplex cytokine/biomarker profiling
Technologies
none stated
Responsibilities
Execute in vivo pharmacology studies supporting target validation, lead optimization, mechanism-of-action, and efficacy evaluation; perform mouse oncology studies using various models; conduct routine and advanced in vivo procedures including dosing, tumor measurement, blood collection, necropsy, and surgeries; prepare tissue for histology and IHC shipment; extract RNA/DNA/Protein and process lysates for downstream analysis; evaluate and implement emerging in vivo models and ex vivo assay technologies; maintain detailed experimental documentation and contribute to study reports
Seniority
Mid-Senior, hands-on IC