Senior / Principal Scientist, Structural Biology — Target Druggability & Structure-Based Drug Design
Core
Define target tractability strategies and design experimental campaigns to solve unprecedented structures for challenging drug targets.
Role type
Senior/Principal Scientist, Structural Biology (Target Druggability & SBDD)
Builds
Novel therapeutics and materials applications
Domain
Biopharmaceuticals / Structure-Based Drug Design
Deliverable
production ML models | product features
Required skills
Structural biology, Biophysics, Computational chemistry, Cryptic/transient binding site identification, Pocket druggability assessment, Cryo-EM, X-ray crystallography, AI-based structure prediction, MD-based conformational sampling, Binding site detection algorithms, Structure refinement
Preferred skills
Modality-switch programs (biologic-to-small-molecule, PROTAC), Generative structure prediction, MD-based ensemble docking, AI-based ligandability prediction
Technologies
Glide, FEP+, BioLuminate, Prime
Responsibilities
Define druggability hypotheses integrating structural/computational/biophysical evidence; Apply AI/ML for structure prediction and binding site identification; Translate insights into actionable hypotheses for medicinal chemistry; Evaluate and integrate emerging methods into workflows; Present tractability assessments to stakeholders; Lead experimental structural biology efforts (CRO management or hands-on lab work); Contribute to platform strategy.
Seniority
Senior/Principal, hands-on IC with strategy & mentorship