gRNA Process Development Scientist
Core
Develop and optimize manufacturing processes for guide-RNA (gRNA) drug substances in clinical development programs.
Role type
Process development scientist (oligonucleotide manufacturing)
Builds
gRNA drug substance manufacturing processes and controls
Domain
Biopharmaceuticals / Oligonucleotide synthesis
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
solid-phase synthesis, purification, HPLC, UV-Vis, buffer preparation, TFF, SOP adherence, electronic lab notebooks, lab safety
Preferred skills
CRISPR gRNA development, longmer synthesis
Technologies
Akta chromatography, Agilent U/HPLC, gel electrophoresis, NanoDrop, Benchling
Responsibilities
Execute solid-phase synthesis and purification experiments; perform routine analytics; prepare buffers and reagents; compile and present data; maintain lab equipment and notebooks; uphold lab safety standards
Seniority
Mid-level, hands-on IC