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Research Fellow, Computational Chemistry – 8+ years

Lyon, Auvergne-Rhône-Alpes, fr💼 Full-time🗓 2026-04-29 → 2026-07-31

Core

Lead computational chemistry initiatives and AI/ML integration to advance drug discovery from hit identification to clinical candidate selection.

Role type

Senior IC computational chemistry research fellow

Builds

In silico drug discovery workflows, computational software, and data-driven design hypotheses for pharmaceutical clients

Domain

Pharmaceutical drug discovery and computational chemistry

Deliverable

production ML models | product features

Required skills

computational chemistry methods, medicinal chemistry principles, ligand-based design (QSAR, similarity searching), free energy methods (FEP, MM-GBSA), large dataset curation, modern AI/ML in drug discovery, statistical thinking, cross-functional collaboration

Preferred skills

lead optimization support, ADMET prediction tool integration, experimental data assessment (SAR, assay variability), leadership and mentoring, strategic deployment of AI/ML approaches

Technologies

docking and scoring software, computer-aided drug design (CADD) simulation tools, data-mining and visualization platforms

Responsibilities

Represent Computational Chemistry as subject matter expert for nonclinical R&D; Independently pursue research projects and implement novel computational workflows; Contribute to development of state-of-the-art computational software and CADD techniques; Analyze, interpret, and report research informatics data; Partner with medicinal chemistry teams on lead optimization (docking, scoring); Apply or develop new tools for integrative analysis of large datasets; Participate in data governance objectives; Provide regular communication on project status and strategies to leadership; Ensure project alignment with company policies and EHS requirements

Seniority

Senior, hands-on IC with research leadership

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