Scientist, mRNA Downstream Purification
Core
Lead downstream process development and scale-up for mRNA drug substance purification.
Role type
Scientist, downstream process development (mRNA biologics)
Builds
mRNA drug substance for discovery and preclinical studies
Domain
Biotechnology / mRNA therapeutics / Epigenetic reprogramming
Required skills
downstream purification process design, tangential flow filtration (TFF), ÄKTA chromatography operation, experimental design and troubleshooting, complex data analysis, technical writing
Preferred skills
nucleic acid purification methods, plasmid DNA purification, Design of Experiments (DoE), automated high-throughput workflows, CDMO tech transfer, cGMP process development, mRNA analytics (HPLC, CGE, dsRNA ELISA)
Responsibilities
Design and execute process development studies for mRNA purification; Act as downstream lead for CMC program teams; Design and implement automated downstream workflows; Support process scale-up from bench to pilot; Evaluate emerging purification technologies and chromatography resins; Perform tech transfer of downstream processes to CDMOs; Act as person in plant during CDMO manufacturing runs; Support process troubleshooting and deviation investigations at CDMOs; Author development SOPs and technical development reports
Seniority
Mid-level Scientist (0-3 years PhD or 5+ years MS/BS)