Associate Scientist/Engineer II Technology, Development and Operations - Chemistry
Core
Develop, optimize, and transfer manufacturing processes for solid-phase chemical synthesis of long guide RNA and downstream purification (chromatography, TFF, lyophilization) to support Prime Editing gene therapies.
Role type
Associate Scientist/Engineer II, Chemistry (Process Development & Manufacturing)
Builds
IND-enabling and GLP/GMP RNA guides for Prime Editing programs
Domain
Biotechnology / Gene Editing / RNA Chemistry
Required skills
solid-phase chemical synthesis, downstream purification (chromatography, TFF, lyophilization), GMP manufacturing operations, equipment qualification and troubleshooting, SOP and batch record authoring, statistical process analysis, hands-on operation of ÄKTA synthesizers, HPLC, and TFF skids
Preferred skills
oligonucleotide synthesis, process development of complex biomolecules, AI tools for CMC optimization
Technologies
ÄKTA synthesizers, AKTA purifiers, preparative scale HPLC, TFF skids, JMP
Responsibilities
Perform solid-phase chemical synthesis and downstream purification at different scales; conduct hands-on manufacturing of IND-enabling and GLP/GMP RNA guides; maintain lab instruments in good operational conditions; author technical reports, SOPs, and draft batch records; present experimental data in written and oral formats; critically evaluate experimental data and communicate scientific findings.
Seniority
Mid-level, hands-on IC