Scientist, Metabolism
Core
Develop and perform assays for hepatocyte function and evaluate epigenetic reprogramming payloads in preclinical models of liver disease to restore youthful function in aged hepatocytes.
Role type
Senior IC scientist (liver biology and metabolism)
Builds
Preclinical therapeutic candidates for metabolic disease via epigenetic reprogramming
Domain
Biotechnology / Epigenetics / Liver Biology
Required skills
primary liver cell isolation, functional characterization of hepatocytes, mouse models of liver dysfunction, transgenic manipulation of liver cells (ex vivo/in vivo), viral vectors, nucleic acid delivery, experimental design, data analysis
Preferred skills
drug development program contribution, leading preclinical study design, single cell genomics, pooled screening approaches (CRISPR fitness screens, Perturb/CROP-seq)
Responsibilities
Design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes; Develop assays to preclinical models of liver disease to measure hepatocyte function; Evaluate epigenetic reprogramming payloads using in vivo functional assays to select therapeutic candidates; Deliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods; Analyze and interpret experimental data to drive pre-clinical decision making
Seniority
Senior, hands-on IC