Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MA
Core
Designing and optimizing in vitro screening cascades to validate drug targets and bridge computational predictions with experimental reality for oncology and immunology programs.
Role type
Senior In Vitro and Cellular Pharmacologist
Builds
High-quality biological data packages for IND-enabling studies and candidate selection
Domain
Drug discovery / Biophysics / Cell Biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Design of biological screening cascades, Biophysical assays (SPR, ITC), Biochemical assays, Cellular functional assays, CRO management, Data synthesis for strategic decision-making
Preferred skills
Leading biology from inception to clinical candidate, Partnering with Data Science groups for data ingestion, Experience with alternative modalities (peptides, molecular glues), Knowledge of ML in drug discovery
Technologies
SPR, ITC, Enzymatic methodologies
Responsibilities
Design efficient biological screening cascades for internal and partnered drug design programs; Guide optimization of biophysical and biochemical assays; Direct development of functional and phenotypic cellular assays; Work with CROs to design decision-making experiments; Evaluate and synthesize complex binding, kinetic, and dose-response information
Seniority
Senior, hands-on IC