Scientist I/II - Cardiovascular & Metabolic Diseases Pharmacology
Core
Scientist designing and executing integrated in vitro and in vivo pharmacology studies for oligonucleotide discovery programs targeting obesity and MASH.
Role type
Senior IC pharmacologist (RNA therapeutics)
Builds
Preclinical data for ASO and siRNA drug candidates
Domain
Biopharma / RNA therapeutics / Metabolic diseases
Required skills
in vitro and in vivo study design, ASO and siRNA transfection, rodent study execution, metabolic cell culture, molecular biology assays, statistical analysis, IACUC protocol management
Preferred skills
metabolic pharmacology expertise, RNA therapeutics background
Technologies
Seahorse XF, GraphPad Prism, Excel, ImageJ, qPCR, Western blot, ELISA, Luminex
Responsibilities
Design and execute integrated in vitro and in vivo studies; Perform ASO and siRNA transfection studies; Conduct dose-response and time-course experiments; Culture and maintain metabolic cell models; Execute efficacy and PK/PD studies in mouse models; Analyze experimental data and prepare scientific reports
Seniority
Senior, hands-on IC