Scientist/Senior Scientist - Oligonucleotides ADME/PK & Bioanalytics
Core
Lead ADME, pharmacokinetics (PK), biodistribution, and bioanalytical strategy for oligonucleotide therapeutics to advance programs from discovery through preclinical development.
Role type
Senior Scientist, preclinical DMPK & bioanalytics
Builds
Preclinical proof-of-concept data and IND-enabling studies for RNA-based therapeutics
Domain
Biotechnology / RNA therapeutics / Pharmacokinetics
Required skills
Oligonucleotide PK study design, Tissue biodistribution analysis, Bioanalytical assay development (qPCR, LC-MS/MS), Project leadership, CRO management, Translational modeling
Preferred skills
Extrahepatic delivery expertise, Metabolic disease models experience
Technologies
qPCR, SL-RT-PCR, Hybridization ELISA, LC-MS/MS
Responsibilities
Design and execute PK studies in rodent and non-rodent models; Develop and validate bioanalytical assays for oligonucleotide quantification; Integrate PK/PD and biodistribution data to inform candidate selection; Lead preclinical proof-of-concept for extrahepatic delivery platforms; Oversee external CRO studies
Seniority
Senior, hands-on IC