Scientist/Senior Scientist, RNA Analytical Development – Singapore
Core
Establish analytical development processes and phase-appropriate strategies for RNA raw materials, drug substances, and drug products to support platform scalability and pipeline programs.
Role type
Senior Scientist, RNA Analytical Development
Builds
Robust, scalable analytical workflows for nucleic acid therapeutics
Domain
Biopharmaceuticals / RNA therapeutics
Required skills
Analytical chemistry, LC-MS, LC-HRMS, CE-SDS, DSC, HIC, NMR, multiscale purification methods, method validation, QbD principles, regulatory compliance, LIMS/ELN systems
Preferred skills
IND-enabling studies experience, automated high throughput capabilities
Technologies
HPLC, LC-MS, CE, UV spectroscopy, qPCR, DLS, TEM, preparative RP-HPLC, affinity chromatography, ion-exchange, hydrophobic interaction chromatography, size exclusion chromatography, tangential flow filtration
Responsibilities
Develop and execute analytical characterization strategies for RNA materials; Select and implement analytical workflows using orthogonal techniques; Apply QbD principles to define CQAs; Collaborate with cross-functional teams; Develop and maintain SOPs and validation plans; Maintain records in LIMS/ELN systems; Prepare technical reports and documentation.
Seniority
Senior, hands-on IC