Modelling and Simulation PK/PD Expert
Core
Design and oversee complex preclinical studies using mathematical modelling to predict human pharmacokinetics and pharmacodynamics, informing target selection, dosing strategies, and translational development decisions for cardiovascular, renal, and metabolic diseases.
Role type
Senior IC quantitative modelling scientist (PK/PD)
Builds
Quantitative insights and dosing regimens for drug discovery projects
Domain
Pharmaceutical R&D, Cardiovascular/Renal/Metabolic therapeutics
Deliverable
production ML models
Required skills
Model-based PK/PD, NLME, PBPK, QSP, R, Python, MATLAB, Monolix, NONMEM, AI/ML for quantitative research
Preferred skills
Preclinical/translational PK/PD modelling, multi-modality strategy (small molecules, oligonucleotides, peptides, proteins, antibodies, cell/gene therapies), Simcyp, PK-Sim
Responsibilities
Design and execute complex studies in preclinical disease models, synthesize multi-source data to predict human PK/PD, present quantitative assessments to senior stakeholders, lead strategic DMPK and PK/PD innovation projects
Seniority
Senior, hands-on IC
