Principal Bioninformatics Scientist
Core
Lead bioinformatics strategy, design, and development of next-generation minimal residual disease (MRD) laboratory-developed tests (LDTs) for cancer diagnostics.
Role type
Principal Bioinformatics Scientist (Senior Technical Leadership)
Builds
Production-ready bioinformatics pipelines and clinically actionable MRD diagnostics for multiple cancer indications.
Domain
Oncology diagnostics, ctDNA biology, NGS-based assays
Deliverable
production ML models | product features
Required skills
NGS-based oncology assay development, ctDNA biology, Python (production-grade pipelines), design-controlled regulated environment experience, variant detection strategies, error suppression, assay lifecycle management, wet-lab collaboration
Preferred skills
AWS workflow deployment, germline/somatic mutation processes, R, relational/non-relational databases
Technologies
Python, AWS (EC2, S3, Step Functions, Batch, Lambda), R
Responsibilities
Lead bioinformatics strategy for MRD assay design and lifecycle management; Design and execute analytical studies for assay performance; Develop and validate scalable bioinformatics pipelines; Partner with wet-lab, clinical, QA, and software teams; Mentor junior scientists; Contribute to regulatory submissions and audits
Seniority
Principal, hands-on technical leadership with mentorship
