Principal Scientist – Protein Formulation & Biophysical Characterization (High-Concentration Biologics)
Core
Developing and implementing novel formulation strategies and platform approaches for high-dose, patient-centric biologic delivery, including subcutaneous administration.
Role type
Principal Scientist, hands-on IC with technical leadership
Builds
Scalable protein formulations and enabling technologies for high-concentration biologics
Domain
Biologics and vaccines formulation
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Protein formulation for parenteral biologics, Biophysical/analytical characterization (DLS, DSC, DSF, SEC-MALS, NTA, CD, FTIR, fluorescence spectroscopy, rheology), Data analysis and interpretation, Parenteral dosage forms knowledge, Cross-functional collaboration, Technical project leadership
Preferred skills
Protein design/engineering principles, Structure-function relationships, Developability hot spots identification, Elevated protein concentration challenges (viscosity, aggregation, LLPS), Subcutaneous drug delivery fundamentals, Oligonucleotides/peptides formulation, Molecular modeling/simulations
Technologies
DLS, DSC, DSF, SEC-MALS, NTA, CD, FTIR, fluorescence spectroscopy, rheology
Responsibilities
Design and execute experimental studies to develop and optimize protein formulations, Apply biophysical characterization to assess and mitigate risks (aggregation, viscosity, stability), Develop novel formulation strategies and enabling technologies, Build collaborations with academic and industry partners, Lead cross-functional initiatives for subcutaneous delivery of biologics
Seniority
Principal, hands-on IC with technical leadership
