Scientist II, Functional Bioassays & High Throughput Screening
Core
Develop, optimize, and execute functional biochemical and cell-based assays to generate high-quality data guiding protein design and therapeutic program decisions.
Role type
Scientist II, functional bioassays & high-throughput screening
Builds
Functional assay data and screening results for protein design and therapeutic optimization
Domain
Biotechnology / Drug Discovery / Functional Biology
Required skills
cell-based assay development, biochemical assay design, high-throughput screening (384/1536-well), mammalian cell culture, plate-based assay technologies (ELISA, HTRF, AlphaLISA, luminescence, fluorescence), flow cytometry, data analysis (Spotfire, Dotmatics, ScreenWorks, Harmony, iQue), troubleshooting, electronic laboratory notebooks
Preferred skills
ion-channel assays (patch clamp, membrane-potential, thallium-flux), GPCR assays (reporter, calcium-flux, cAMP, IP-one, beta-arrestin), ADC assays, image-based internalization, organoid screening, primary cell culture, laboratory automation (HighRes, Biomek, Hamilton, EL406, Multidrop)
Responsibilities
Design and implement high-throughput screening-compatible assays; execute plate-based screening campaigns and analyze datasets; troubleshoot assay performance and instrumentation; maintain accurate records in electronic laboratory notebooks; coordinate experiments across cross-functional teams; communicate findings to inform design cycles and program decisions.
Seniority
Mid-level Scientist (2+ years industry/postdoc or 5+ years MS/7+ years BS experience)
