Principal Scientist, Target Binding
Core
Lead Target Binding strategy and execution for protein–protein interaction, target-binding, and cell-binding measurements across biotherapeutic discovery and development programs.
Role type
Principal Scientist (Biophysics & Protein Analytics)
Builds
Quantitative biophysical assays and measurement platforms for biotherapeutics
Domain
Biopharmaceuticals / Protein Biophysics
Deliverable
production ML models
Required skills
SPR, BLI, KinExA, cell-binding assays, integral membrane protein characterization, assay development, quantitative modeling, machine learning, statistical analysis, team leadership
Preferred skills
biotherapeutic analytics, developability assessment, laboratory automation, high-throughput experimentation, AI-enabled tools, scripting
Technologies
SPR, BLI, KinExA, machine learning frameworks, data science pipelines
Responsibilities
Lead Target Binding strategy and execution across multiple programs; Design, develop, optimize, and oversee quantitative protein–protein interaction and cell-binding assays; Develop fit-for-purpose approaches to measure affinity, kinetics, stoichiometry, competition, and thermodynamics; Lead assay development for challenging molecular systems including integral membrane proteins and multispecific molecules; Advance the Target Binding technology platform by evaluating emerging technologies and developing novel automated or computationally enabled approaches; Establish standards for assay quality, instrumentation, data processing, and reproducibility; Apply quantitative, statistical, machine-learning, and agentic approaches to improve experimental design and decision-making; Directly manage, mentor, and develop junior scientists and research associates.
Seniority
Principal, hands-on IC with strategic leadership