Senior Director, Cardiovascular and Cardiometabolic Translational Biology
Core
Senior Translational Biology expert leading cardiovascular and cardiometabolic disease strategy, target evaluation, and portfolio development within a pharmaceutical R&D unit.
Role type
Senior Director, Translational Biology (Individual Contributor with Matrix Leadership)
Builds
A differentiated portfolio of cardiovascular and cardiometabolic medicines by defining human-relevant mechanistic hypotheses and translational strategies.
Domain
Pharmaceutical R&D, Cardiovascular and Cardiometabolic Biology
Required skills
Cardiovascular biology, Preclinical biology, Forward and reverse translation, Human genetics, Multi-omics, Biomarker strategy, Target selection, Business development, Academic partnership management, Portfolio resourcing
Preferred skills
None stated
Technologies
Human genetics, Multi-omics, Advanced analytical methodologies
Responsibilities
Define clear human-relevant mechanistic hypotheses for preclinical and clinical portfolios; Drive programs on vascular inflammation, endothelial dysfunction, fibrosis, remodeling, thrombosis, pulmonary vascular disease, heart failure, and cardio-renal-metabolic pathways; Provide leadership on biomarker strategies for target engagement and patient selection; Align stakeholders on study design and decision quality; Partner with clinical, genetics, and platform teams to interpret complex datasets; Identify opportunities for novel therapies and next-generation translational approaches; Evaluate business development opportunities; Establish strategic collaborations with academic institutions and external experts; Ensure adherence to regulatory expectations and quality standards.
Seniority
Senior Director, hands-on IC with matrix leadership