Principal Research Scientist I, Biologics CMC Developability Modeling
Core
Lead modeling efforts to develop models of protein structure and function, utilizing biophysical and analytical instrumentation to assess drug candidates and solve foundational questions like viscosity, chemical degradation, and aggregation.
Role type
Principal Research Scientist (Biologics CMC Developability Modeling)
Builds
Predictive models for protein stability and formulation screening to augment decision making in protein design and development
Domain
Biopharmaceuticals / Protein Engineering / Machine Learning
Deliverable
production ML models
Required skills
mechanistic and statistical modeling, predictive machine learning, deep learning, hierarchical/multi-task frameworks, feature attribution, sensitivity analysis, model interpretability, biochemistry experimentation design
Preferred skills
knowledge of protein solution behavior, cross-functional decision making
Technologies
high throughput instrumentation, digital data systems
Responsibilities
Serve as technical expert for modeling within the team; represent the team in modeling communities; perform in vitro laboratory experiments and design wet lab studies; identify emerging scientific trends and integrate them into plans; present data at conferences and prepare manuscripts; coordinate developability assessment activities for Discovery Projects
Seniority
Principal, hands-on IC with mentorship
