Senior Scientist II- Hepatocyte and Liver Tissue Engineering
Core
Lead scientific execution and experiment planning for expanding, engineering, and characterizing functional human hepatocytes to develop engineered liver tissue for treating liver failure.
Role type
Senior Scientist II, hands-on IC
Builds
Engineered liver tissue constructs and functional hepatocyte cell lines
Domain
Biomedical research / Tissue engineering / Cell therapy
Required skills
Human cell culture and expansion, Genetic engineering (CRISPR/Cas9), Assay development, Data analysis, Laboratory operations, Scientific writing
Preferred skills
Primary human hepatocyte experience, Stem cell-derived cell experience, cGMP manufacturing, IND-enabling studies, 3D culture and organoids, IP strategy
Technologies
CRISPR/Cas9, Bioreactor systems, In vivo models
Responsibilities
Design and conduct core experiments for hepatocyte workstream, Optimize methods for hepatocyte maturation and maintenance, Develop genetic engineering strategies to modulate immunogenicity, Integrate engineered hepatocytes into tissue constructs, Lead milestone planning and sponsor reporting, Supervise technicians and mentor research staff
Seniority
Senior, hands-on IC