Senior Scientist II, Recombinant Peptide Process Development
Core
Lead development of microbial-based recombinant peptide production processes, addressing challenges like degradation and solubility, and applying genetic code expansion strategies.
Role type
Senior Scientist II, Recombinant Peptide Process Development
Builds
Robust, scalable processes for therapeutic peptide production
Domain
Biologics CMC / Recombinant Peptide Manufacturing
Required skills
microbial physiology, recombinant expression systems (E. coli, yeast), strain/clone screening, fermentation, process optimization, preparative chromatography, peptide purification, fusion-partner cleavage, HPLC/UPLC/LC-MS data interpretation, AI/ML for data analysis
Preferred skills
complex therapeutic peptide manufacturing (GLP-1/incretins), genetic code expansion, non-canonical amino acid incorporation
Technologies
E. coli, yeast, microscale cultivation, parallel bioreactors, HPLC, UPLC, LC-MS
Responsibilities
Lead recombinant peptide process-development activities including expression strategy, host/clone screening, and scale-up; Design and evaluate expression constructs and microbial hosts; Develop fusion-tag and carrier-protein strategies; Design and conduct clone-screening studies; Develop and optimize peptide recovery processes; Troubleshoot peptide-specific process challenges; Interpret analytical results (HPLC, UPLC, LC-MS); Evaluate emerging technologies including genetic code expansion; Apply AI/ML approaches to analyze data; Mentor junior scientists
Seniority
Senior, hands-on IC