Principal Scientist I - Quantitative, Translation & ADME Sciences
Core
Lead a team of junior scientists to drive cutting-edge quantitative ADME science, implementing innovative in vitro models and translational modeling concepts to advance drug candidates in the pipeline.
Role type
Principal Scientist, strategic scientific leadership in in vitro ADME
Builds
Translational mechanistic models for early and late-stage small molecules
Domain
Pharmaceutical R&D, Drug Metabolism and Pharmacokinetics (DMPK)
Deliverable
production ML models
Required skills
Drug metabolizing enzyme function, drug-drug interaction concepts, quantitative bioanalysis, in vitro assay design, IVIVE, DDI risk assessment, enzyme kinetics, strategic scientific leadership, team mentorship
Preferred skills
Drug permeability and transport, receptor pharmacology, pharmacokinetic modeling, new technology implementation
Technologies
In vitro models, quantitative approaches
Responsibilities
Evaluate novel in vitro tools and methods to predict human PK and DDI potential; Lead, mentor and coach junior staff in in vitro drug metabolism; Liaise with discovery biology/pharmacology/chemistry scientists to generate data for translational models; Communicate on in vitro drug metabolism topics; Keep up to date with emerging literature in modeling and in vitro approaches; Externalize research via publications and presentations.