Senior Scientist I, Experimental & Systems Immunology
Core
Design and execute human disease-relevant immunology experiments using primary human cells and complex in vitro models to identify and validate therapeutic targets for autoimmune and inflammatory diseases.
Role type
Senior Scientist I, Experimental & Systems Immunology
Builds
Novel therapeutic targets and mechanistic insights for autoimmune and inflammatory diseases
Domain
Biopharmaceuticals / Immunology / Systems Biology
Required skills
Experimental design and execution, Primary human cell handling (PBMCs, tissues), Complex in vitro model development (organoids, co-cultures), High-throughput assay development, Flow cytometry, Cytokine profiling, Gene expression analysis, Statistical data analysis, Multidisciplinary collaboration
Preferred skills
Single-cell genomics, Spatial biology, Multi-omics profiling, Next-generation sequencing (10x Genomics), Target validation, Mechanism-of-action studies, Data science approaches to biology
Technologies
R, Python, GraphPad Prism, Spotfire, 10x Genomics Chromium
Responsibilities
Design and execute immunology-focused experiments using primary human cells and disease-relevant model systems; Characterize complex in vitro models using high-throughput methodologies; Develop assays to characterize immune cell function and therapeutic mechanisms; Analyze data from flow cytometry, cytokine profiling, NGS, and single-cell/spatial workflows; Partner with computational biologists and disease-area teams to prioritize targets; Apply statistical approaches to analyze complex datasets; Present findings to project teams and leadership.
Seniority
Senior, hands-on IC