Scientist II / Senior Scientist I, tLNP Process Development
Core
Develop end-to-end manufacturing processes for targeted lipid nanoparticles (tLNPs) to deliver mRNA therapeutics, from encapsulation and bioconjugation to purification and scale-up.
Role type
Senior IC process development scientist (mRNA-LNP manufacturing)
Builds
Pre-clinical and GMP clinical supplies of tLNP bulk drug product
Domain
Biopharmaceuticals / mRNA therapeutics / Chemical Engineering
Required skills
mRNA encapsulation, bioconjugation, tangential flow filtration (TFF), LNP mixing technology, laboratory automation, statistical modeling, scientific writing, regulatory document preparation
Preferred skills
Scaling LNP processes to gram-scale, automation ecosystem integration (e.g., Ignition)
Technologies
Impinging jet mixers, coaxial jet mixers, multi-inlet vortex mixers, tangential flow filtration (TFF), Ignition
Responsibilities
Design and execute experiments for unit operations (encapsulation, bioconjugation, TFF) and scale to commercial batch sizes; Develop and implement innovative automation solutions; Lead tech transfer of commercial processes; Author publications, presentations, and regulatory documents; Mentor team members.
Seniority
Senior, hands-on IC