Principal Scientist I - Pharmacology
Core
Lead quantitative ADME science and in vitro drug metabolism research to drive translational modeling and predict human PK/DDI for small molecule drug candidates.
Role type
Principal Scientist I, hands-on IC with strategic leadership
Builds
Translational mechanistic models and in vitro ADME strategies for early and late-stage drug candidates
Domain
Pharmaceutical R&D, Drug Metabolism and Pharmacokinetics (DMPK), In Vitro ADME
Deliverable
production ML models
Required skills
Drug metabolism, enzyme kinetics, IVIVE, DDI risk assessment, in vitro assay design, quantitative bioanalysis, pharmacokinetic modeling, strategic scientific leadership, publication record
Preferred skills
Drug permeability, transport, receptor pharmacology, new technology implementation
Technologies
In vitro models, quantitative approaches
Responsibilities
Evaluate novel in vitro tools and methods to predict human PK and DDI; Lead and mentor junior staff in in vitro drug metabolism; Liaise with discovery teams to build translational models; Communicate research findings internally and externally; Keep up to date with emerging literature in modeling and in vitro approaches; Externalize research via publications and presentations
Seniority
Principal, hands-on IC with strategic leadership