Senior Scientist I/II, Analytical Development
Core
Lead analytical method development and characterization for mRNA-based therapeutics and lipid nanoparticle formulations, supporting pipeline advancement and candidate selection.
Role type
Senior Scientist I/II, Analytical Development (mRNA/Lipid Nanoparticles)
Builds
Robust analytical methods and workflows for RNA, lipids, and biologics characterization
Domain
Biopharmaceuticals / mRNA therapeutics / Lipid nanoparticles
Required skills
Analytical method development, RNA/lipid characterization, liquid chromatography (UV, CAD, MS, MALLS, Fl), capillary electrophoresis, plate-based assays, data interpretation, technical writing, cross-functional collaboration
Preferred skills
mRNA drug substance characterization, mass photometry, automated/high-throughput workflows, method transfer/qualification/stability studies, mentoring
Technologies
Liquid chromatography, Capillary electrophoresis, Mass spectrometry, MALLS, Mass photometry, Plate-based assays
Responsibilities
Lead method development for mRNA drug substance and LNP programs; Develop and troubleshoot fit-for-purpose methods for RNA, lipids, and impurities; Design analytical strategies for product characterization and stability; Establish efficient workflows and identify automation opportunities; Investigate complex analytical problems and evaluate emerging technologies; Partner with formulation and process development teams; Represent Analytical Development on platform teams; Provide technical mentorship to junior scientists; Author and review technical reports and protocols
Seniority
Senior, hands-on IC with mentorship responsibilities