Senior Scientist, siRNA Therapeutics & Delivery
Core
Designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics and enable siRNA delivery for extrahepatic pipeline development.
Role type
Senior Scientist I/II (siRNA therapeutics & delivery)
Builds
Novel ex-hepatic siRNA delivery platforms and RNA-based therapies
Domain
Biopharmaceuticals / RNA therapeutics
Required skills
siRNA sequence design and optimization, in vitro and in vivo study design, cellular uptake assessment, target knockdown evaluation, delivery efficiency analysis, biodistribution assessment, molecular biology techniques, RNA extraction and quantification, NGS, protein quantification, flow cytometry, assay development and troubleshooting
Preferred skills
siRNA and antibody-oligo-conjugates (AOCs) experience
Technologies
RT-PCR, qPCR, ddPCR, NGS, ELISA, Western Blot, JESS, flow cytometry
Responsibilities
Lead research efforts to advance siRNA therapeutics development for ex-hepatic pipelines, Design and develop novel ex-hepatic siRNA delivery platforms, Conceive and execute proof-of-concept experiments, Develop in vitro, ex vivo, and in vivo assays, Work independently to maintain high productivity in the laboratory, Analyze and interpret multidisciplinary data, Contribute as primary author to scientific publications and patent applications, Mentor junior scientists
Seniority
Senior, hands-on IC