Senior Scientist, siRNA Design and Off-Target Analysis
Core
Design and optimize siRNA sequences with enhanced knockdown efficacy and reduced off-target liabilities, and develop off-target assessment workflows integrating transcriptomic and genomic data.
Role type
Senior Scientist, siRNA Design and Off-Target Analysis
Builds
siRNA sequences, off-target assessment workflows, and reusable analysis pipelines
Domain
Biotechnology / RNA therapeutics / Computational Biology
Deliverable
production ML models | product features | dashboards & analysis
Required skills
siRNA sequence design, off-target analysis, NGS library preparation, transcriptomic data analysis, machine learning model development, Python/R programming, molecular and cellular biology, scientific reporting
Preferred skills
multi-omics data integration, RNAi mechanisms, LLM-assisted scientific workflows
Technologies
Python, R, NGS, machine learning
Responsibilities
Establish and improve pipelines for siRNA sequence design integrating genomic, transcriptomic, and RNA structural data; Build machine learning models based on high-throughput siRNA screening data; Collaborate on NGS library preparation for off-target analysis; Interpret transcriptomic data to identify off-target signals and biological risk; Develop and maintain reusable tools, scripts, and pipelines; Generate data analysis reports, slide decks, and technical summaries; Collaborate with cross-functional partners to translate findings into actionable insights; Support validation studies relevant to seed-mediated and sequence-dependent off-target effects.
Seniority
Senior Scientist I or II